Spreading Property of Azoproteins in the Dermis by Albert Claude, M.d
نویسنده
چکیده
The presence in testicle extracts of a factor enhancing the lesions produced by infectious agents was demonstrated by Duran-Reynals (1). Subsequently McClean (2) and Hoffman and Duran-Reynals (3) reported that testicle extract had the power to diffuse through certain tissues, especially the connective tissue of the skin. Extracts from other mammalian organs were found to have these properties, though to a lesser degree (4, 5). Attempts by several workers to demonstrate similar properties with a variety of chemicals and with natural products from animal tissues were unsuccessful (6). In the course of a study dealing with the effect of tryptic digestion on the spreading power of testicle extract we were led to test the action of certain diazo compounds on skin permeability. These compounds proved to be very active diffusing agents. The results obtained with sulfanilic acid derivatives have been reported in a preliminary note (7). The properties of the diazo and azo compounds have been studied further and the specificity of the active chemical group has been investigated.
منابع مشابه
Spreading Property of Azoproteins in the Dermis
1. Azoproteins are shown to have the property of spreading when introduced intradermally into the rabbit skin. 2. The aromatic derivative selected for the coupling does not affect specifically the spreading property of the azoprotein. Likewise, the type of protein has no importance, except in quantitative respects. 3. The spreading property conferred upon a protein by coupling appears to derive...
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It is known that azoprotein solutions, like testicular extracts, possess the property of causing particles to spread through the dermis. The present work shows that azoproteins exhibit, like testicular extract, the power to increase the size of virus lesions in the skin of rabbits, and the size of tumors in chickens. The results indicate that the extent of the lesion is roughly proportional to ...
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تاریخ انتشار 2003